“When periodontitis occurs, reactive oxygen species, which are overproduced mostly by hyperactive neutrophils, could not be balanced by antioxidant defense system and cause tissues damage. This is characterized by increased metabolites of lipid peroxidation, DNA damage and protein damage”
“Inflammaging, defined as an age-related increase in the levels of pro-inflammatory markers in blood and tissues, is a strong risk factor for multiple diseases that are highly prevalent and frequent causes of disability in elderly individuals but are pathophysiologically uncorrelated.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/
“Known since antiquity, periodontitis became prevalent after the domestication of plants and animals in Neolithic societies (≈10,000 years ago) when the oral microbiota underwent a distinct compositional shift — with increased frequency of Porphyromonas gingivalis and other periodontitis-associated species — compared with earlier hunter-gatherer societies. In its severe form, which afflicts 8.5% of U.S. adults, […]
“Periodontal tissues require adequate levels of antioxidants to prevent tissue damage caused by reactive oxygen species….Antioxidants are compounds that prevent the initiation or progression of oxidation reactions by trapping oxygen in the environment. They play an important role in preserving the structural integrity of cells and tissues, by maintaining their normal functions and ensuring the […]
“Ayurvedic drugs have been used since ancient times to treat oral diseases including periodontal diseases. Sushruta Samhita in his 20th shloka has stated that Triphala can be used as a gargling agent in dental diseases as it has antibacterial, antiseptic, and anti-inflammatory properties. Polymorphonuclear neutrophils (PMN) provide the major source of collagenases or gelatinase that […]
A study by Kendwal in 2015 compared turmeric (curcumin) to prescription chlorhexidine gel in 60 patients over 21 days and found similar results for curcumin with better acceptance due to a more pleasant taste compared to chlorhexidine.
About 5% to 20% of the population suffers from severe, generalized gum disease. For those who are most at risk, the disease becomes evident in teenage and early adult years rather than the later years. Risk factors for gum (periodontal) disease include smoking, genetic predisposition, psychosocial stress, diabetes, and some rare systemic (whole body) diseases. […]
A total of 6 studies compared the ulcer healing time and treatment time. In comparison with the control group, the ulcer healing time was reduced by 2.15 days and the treatment time was reduced by 2.32 days. https://apm.amegroups.com/article/view/72221/html
The damage from Gum Disease is due to inflammation and oxidative stress. Oxidative stress is the disturbance in the pro-oxidant and antioxidant balance towards oxidation resulting in tissue damage. “Dental Plaque build-up allows the growth of anaerobic bacteria, which eventually leads to the recruitment and activation of neutrophils. This further results in the upregulation of […]
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